These animals require the opposite regimen. Feline idiopathic ulcerative dermatosis treated successfully with oclacitinib. Olivry T, Banovic F. Treatment of canine atopic dermatitis: time to revise our strategy? Vet Dermatol 2015;26:134 (abstract). Proc (Bayl Univ Med Cent) 2018;31(4):524-525. Gadeyne C, Little P, King VL, et al. Cyclosporine, which is approved for the treatment of canine atopic dermatitis, has an onset of efficacy of up to 4 weeks. Weve been doing really well with every other day dosing. Shes on 5 pills once a day for 7 days, after that we will drop to every other day, and then see how far we can space it out. 1. But the immune system is not a perfect one. Eur J Pharmacol 2017;794:20-26. The recommended Apoquel dosage for dogs is 0.18 to 0.27 mg per lb of body weight (0.4-0.6 mg/kg) once a day. Because one of mine had similar food allergies and I was told the serum would not address that. I am not saying it is a cure all, but that and some generic Zyrtec make my mare a whole lot more comfortable. Thank you! Horse dosing is 5 pills. By blocking cytokines, Apoquel blocks your dog's skin from itching and inflammation. APOQUEL tablets may be administered with or without food. 23. Veterinarians dose Apoquel at 0.18-0.27mg per pound of bodyweight. Cosgrove SB, Cleaver DM, King VL, et al. Topical suspension administered in the ear. $ 78.30 - $ 245.00. As a result, muscles relax and cause heavy sedation, notes DailyMed. Rosenkrantz WS, Bourgeois AS. Posted by Lucile Vigouroux | May 4, 2022 | Article, Diseases and Conditions, Farm and Barn, Hives & Skin Allergies, Horse Care, Medications, Nutrition, Seasonal Care, Skin Problems. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. When your dog is itchy, you get desperate to make him feel more comfortable. 14. The biggest disadvantages are the cost, the need to acclimate the horse to having the device placed in his or her nostril, poor tolerance by some horses who dislike the device, and the uncertainty about how long your horse will be able to go without repeating the treatment. It is no surprise we see this omega-3-rich plant with anti-inflammatory and antioxidative properties in many skin and allergy supplements. Log in to browse, order and prescribe from our compounded drugs formulary. These reports suggest the potential use of oclacitinib in other diseases; however, it cannot be stressed enough that the use of oclacitinib in these diseases is an off-label use. Pros and cons of oclacitinib therapy. Panteri A, Strehlau G, Helbig R, et al. Vet Dermatol 2018:29:371 (abstract). Skin allergies can also cause pruritus (itching) and associated hair loss. Cosgrove SB, Cleaver DM, King VL, et al. 28. One of my horses was tested at New Bolton (he has since passed away) and I was told that a serum wasnt possible or effective for most of his food-bourne allergies. Its expensive, but its working. The purpose of Apoquel 16mg Tablets for dogs is to alleviate itching related to allergic dermatitis and address the signs of atopic dermatitis. 13. It is an anti-inflammatory drug from the class of drugs known as Janus kinase (JAK) inhibitors. In cats, this medication can cause excitement rather than sedation. A follow-up study assessed the long-term safety, efficacy, and quality of life of oclacitinib-treated dogs. Topics. Transdermal applicator that gives easy & accurate dosing every time. For more information, please see the full Prescribing Information. The recommended dose of Apoquel for dogs is 0.18 to 0.27 mg per pound of body weight. Apoquel Dosage. Aymeric E, Bensignor E. A case of presumed autoimmune subepidermal blistering dermatosis treated with oclacitinib. Log in to fill, refill or renew the medication prescribed by your veterinarian. Not really cheap any way you shake it, but considering that she was on zyretc, dex, smarthbreathe ultra, respi-free previously. In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days. 30. Dosing Chart Warnings Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Anecdotal reports indicate that oclacitinib is not very effective in managing recurrent and/or chronic otitis and interdigital furunculosis associated with allergies, and a sudden loss of efficacy is often associated with bacterial or. Option 3 is using a nebulizer with dexamethasone and/or other drugs. on various factors. She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. The results are problematic. This makes it a common site for the bodys expression of allergic reactions. This is a new treatment option, and currently the tablets are not FDA approved for horses, only dogs. Cosgrove SB, Wren JA, Cleaver DM, et al. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. While efficacy was comparable to that observed in the previous studies, significant positive effects on the dogs quality of life were observed in >91.5% of cases after 630 days. Her allergies have reared their ugly heads again - no jowl pyoderma, but ears itching. Insect and pollen season is here. Horse dosing is 5 pills. Right now he is on an Aservo Inhaler but I dont see any improvement and he is getting real tired of the application process. Allergies are generally managed based on the severity of clinical signs. Use of them does not imply any affiliation with or endorsement by them. So lets review why allergies happen, how they affect your horses body, and how to treat themor, better yet, how to avoid them altogether. For maintenance therapy, the same dose (0.4 to 0.6 mg oclacitinib/kg bodyweight) should then be administered only once a day. Have you considered trying allergy testing? 27. Then, doses ranging from 0.4 to 1.2 mg/kg body weight once daily. Dawn M. Cleaver, DVM Associate Director, Regulatory Affairs Apoquel is the #1 prescribed medicine for fast, effective relief of allergic itch and inflammation due to atopic and allergic dermatitis 1 Indications Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. With a prescription number, easily refill prescriptions and enroll in the AutoRefill Program. Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis. These and other kinase-inhibiting drugs sometimes work very well to stop the itching. The dosage for dogs 10-14.9 lbs is of a 5.4 mg tablet twice daily. Pulsoni D, Freire A, Ferreira DR. Juvenile-onset ischemic dermatopathy. Allergen avoidance and allergen-specific immunotherapy are measures that address the allergy itself; various drugs are available for symptomatic management. Its anti-inflammatory and expectorant properties can soothe irritated lung tissues and help to expel mucus.Licorice root should not be fed to pregnant mares. Recently, researchers have delved into the causes and consequences of what now falls under the umbrella term equine asthma. You may give this medicine with or without food. Therefore, it is important to get your veterinarian involved right away. Dosage and Administration: The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Im hopeful, however, that I will be able to stretch out more so that Im looking at $250 across 8-10 weeks instead. For dogs weighing between 10 and 14.9 pounds, give of a 5.4 mg tablet twice daily as dosage. EHV Quarantine Released at Turf Paradise Racetrack, Six Simple Spring Safeguards for Senior Horses, Evaluating the Suspensory Ligament in Cutting Horses, Regular Dental Care Important in Horses Worldwide, Investigating Equine Cases of Toxicant Exposure, Podotrochlosis: Navicular is No Longer the End of the Road for Horses. For example: 1,000 lb horse X 10 mg/lb = 10,000 mg. Apoquel sorted the problem in a day but after doing some research after noticing her doing some chewing again Apoquel has some disturbing side effects as it suppresses the immune system. Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. Avoiding Allergies Definitely less than a horse lol but 1.5 16mg tabs a day is $$. 405 HERON DRIVE SUITE 200 SWEDESBORO, NJ 08085-1749 | 2004-2023 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED. 30. 2: The Barn and Pasture: Horses with Summer-Pasture-Associated disease usually have less symptoms when kept in the barn during the warmer months. Since oclacitinib is a rather weak anti-inflammatory drug, it was suggested that remission of active moderate to severe atopic dermatitis be induced with a course of a broad inflammation-targeting drug, such as a short-acting glucocorticoid, until clinical signs become mild. Apoquel. If your horses allergies are seasonal, talk to your veterinarian about steps you can take to stay ahead of them. 6. In this study, 70% of the study population receiving oclacitinib showed improvement in pruritus compared with 75% in a group receiving methylprednisolone.18 Based on this study, a higher dose with a longer induction period seems to be the key to successfully treating feline pruritus with oclacitinib. Apoquel is a non-hormonal drug for dogs, used for dermatitis of various etiologies, which are accompanied by itching. Orthobiologic Options for Treating Horses. Researchers have proven flaxseed reduces skin lesions in IBH horses (ONeill et al., 2002). The Vet had put her on Apoquel as an initial dose for 10 days tapering off. Hay replacement consists of any of the following: a complete pelleted diet, soaked alfalfa cubes, hay pellets, or possibly a bagged forage product like Chaffhaye. Hay naturally contains microscopic fungal spores, plus bacterial and dust components that horses inhale as they eat, explains Lisa Fultz, DVM, MS, Dipl. 7. Banovic F, Tarigo J, Gordon H, et al. Clenbuterol dilates the airways, and may improve air flow, but it doesn't treat the inflammation associated with the disease. Frank RK, Galvan BA, Schoell AR, et al. Excitement rather than lethargy can occur occasionally, especially in cats. The drug targets pro-inflammatory proteins, called cytokines, responsible for itching and inflammation, relieving signs of skin allergies. Cosgrove SB, Wren JA, Cleaver DM, et al. There are 4 JAK families in mammals: JAK1, JAK2, JAK3, and TYK2. Oclacitinib preferably inhibits JAK1 and, to a lesser degree, JAK3, resulting in decreased activity of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31). We cannot be sure of accurate dosing when tablets are quartered, and thus this practice is not recommended. Use of oclacitinib (Apoquel; Zoetis) for treatment of cutaneous mastocytosis in a cat. Even though the drug is currently labeled for use in dogs (with allergic dermatitis), initial studies show that horses absorb it well, Fultz says. The anti-inflammatory/immunosuppressive response is confined almost exclusively to the lungs, avoiding a bodywide effect, says Fultz. K. Route of Administration . Please select your state below. He stayed on as a faculty member until 2013, when he decided to move back to Switzerland to open his own dermatology clinic in his hometown of Basel in 2014. 7. Vet Dermatol 2013;24(5):479-e114. This content is intended for counseling purposes only. If your horse's test results (from a BAL or tracheal wash) show a certain cell type in the lungs, we may recommend trying Zyrtec!Clenbuterol: This is a bronchodilator that may be beneficial in treating some horses with Equine Asthma. Apoquel should not be used in breeding, pregnant, or lactating dogs. The Horsesexperts answer your questions during a monthly live audio event. More severe ones, however, can truly take a toll on your horses health and make him miserable. Uses for Apoquel Food allergies in particular you cant always do the serum for. The drug targets pro-inflammatory proteins, called cytokines, responsible for itching and inflammation, relieving signs of skin allergies. If your horse has "classic" RAO, he may have more difficulty in the barn, and need to be kept outside 24/7.3: The Supplements: Studies have shown that horses with Asthma benefit from supplements with Omega 3 fatty acids. Apoquel is a prescription dog allergy medicine used for the control of itch associated with allergic dermatitis and control of atopic dermatitis in dogs 12 months and older. Acepromazine affects animals and humans by depressing the central nervous system. Yamaoka K, Saharinen P, Pesu M, et al. Cats have been reported to drink more water while receiving this drug and also experience be- havior changes while receiving hydroxyzine. All dogs itch sometimes, but when you notice it happening more and more, it could be a sign of a medical condition. Urticaria (hives) is the most widely reported presentation of a skin allergy. Gonzales AJ, Bowman JW, Fici GJ, et al. 3. This treatment is typically effective, but the steroid is still absorbed into the body, which can result in laminitis risk, similar to Option 1. Veterinarians are especially wary of administering corticosteroids to allergic horses that suffer from pituitary pars intermedia dysfunction, insulin dysregulation, and/or equine metabolic syndrome, because these conditions are also risk factors for laminitis. Find out more. Recently, one group has looked into immunomodulatory properties of oclacitinib by observing canine T-cell proliferation and cytokine productions in vitro. 20. I had my dog on it and the price was pretty steep. Dexamethasone: EZ Dose Micro Transdermal Gel, Dexamethasone: Twist-a-Dose Transdermal Gel, Discussion Guide for Pet Owners and Veterinarians, Medication Information for Pet and Horse Owners. 23. The dosage for dogs 15-19.9 lbs is one 3.6 mg tablet twice daily. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Meaning, if a 100lbs dog gets 16mg (1 pill), a horse does not need 160mg (10 pills). Rest assured, your horses are receiving the best possible disease protection. In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days.7,8 Treatment success was based on reductions from baseline of at least 2 cm on the owner-assessed visual analog scale and at least 50% on the clinicians Canine Atopic Dermatitis Extent and Severity Index (CADESI-02). J Zoo Wildl Med 2017;48(3):818-828. Intradermal allergy testing is the gold standard for this and involves a veterinary dermatologist subcutaneously injecting very small quantities of potential allergens into a clipped patch of the horses neck. More studies are necessary to confirm oclacitinibs effects in non-allergic diseases and what other immune-mediated mechanisms may be involved. The most common side effect is lethargy, dry mouth, and urinary retention. Use code GOODRX20 Sponsored by We. Vet Dermatol 2015;26(3):171-179, e35. While easy to perform, Fultz says its not always accurate at predicting the exact allergens. Yamaoka K, Saharinen P, Pesu M, et al. In more severe cases, Apoquel can be given twice per day. Dosage and treatment schedule The recommended initial dose is 0.4 to 0.6 mg oclacitinib/kg bodyweight, administered orally, twice daily for up to 14 days. In some dogs, this can be overcome by splitting the total daily dose in half and give twice daily. That's why dosage is usually tapered down to the lowest effective dose. But I had my mare tested last year, she also came up allergic to some foods (flax being one) for which I was told serum was not an option. Old fashioned drugs like Benadryl and steroids don't work well any more. This treatment option is FDA approved for equine asthma, and is very safe with no known side effects. The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. But you're making a deal with the devil when you use these . Clenbuterol should only be used short-term, since it will stop working with long-term administration. Oral . The dose of Apoquel tablets is 0.18-0.27 mg/lb (0.4-0.6 mg/kg). Lopes NL, Campos DR, Machado MA, et al. Most common side effects are vomiting and diarrhea. With equine allergies, prevention is a horse owners best bet. I know there are some cases where the horse only needs 5 pills 1x a weekothers where its every 4 days.My vet did say she has one client whos horse has gone down to 2 pills every 3 days. Vercelli A, Cornegliani L. Use of oclacitinib in treatment of canine idiopathic ear tip vasculitis. This product is a hand-held device that administers an anti-inflammatory mist into the horses nostril. found a significant improvement in 76% of horses with skin allergies within one year of using allergen-desensitization serums. However, the study showed that cyclosporine caused a 3-fold higher risk for developing gastrointestinal side effects (vomiting and diarrhea) compared with oclacitinib.12, Despite its delayed effects, cyclosporine is still a popular drug to treat canine atopic dermatitis because in some cases it can be dosed every other day or even every third day after initial daily treatment. No claims are made as to the safety or efficacy of mentioned preparations. . Avoid storing hay in the same barn as sensitive horses. Allergies can develop at any time, in any horse, and for virtually any reason. 28. In many cases, symptomatic therapy alone with drugs such as oclacitinib is insufficient to control allergies long-term. Licorice Roo t (Glycyrrhiza glabra) This sweet and soothing herb has been used medicinally for over 3,000 years. Unless my vet (and an unaffiliated nutritionist) I consulted are wrong-- I was told that allergy serum is only possible/effective for some allergies and a lot of food-based ones are not on the list. Option 2 is the Aservo Equihaler. Download Apoquel Information Sheet.